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Research ArticleOriginal Article

Office-Based Evaluation Of Renal Function In Elderly Patients Receiving Nonsteroidal Anti-Inflammatory Drugs

Doyle M. Cummings, Peter Amadio, Steven Nettler and Michael Freedman
The Journal of the American Board of Family Practice April 1988, 1 (2) 77-80; DOI: https://doi.org/10.3122/jabfm.1.2.77
Doyle M. Cummings
From the Departments of Pharmacy and Family Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, and the Department of Medicine, New York University Medical Center. Address reprint requests to Doyle M. Cummings, Pharm.D., Departments of Pharmacy and Family Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107.
Pharm.D.
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Peter Amadio Jr.
From the Departments of Pharmacy and Family Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, and the Department of Medicine, New York University Medical Center. Address reprint requests to Doyle M. Cummings, Pharm.D., Departments of Pharmacy and Family Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107.
M.D.
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Steven Nettler
From the Departments of Pharmacy and Family Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, and the Department of Medicine, New York University Medical Center. Address reprint requests to Doyle M. Cummings, Pharm.D., Departments of Pharmacy and Family Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107.
M.S., M.P.H.
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Michael Freedman
From the Departments of Pharmacy and Family Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, and the Department of Medicine, New York University Medical Center. Address reprint requests to Doyle M. Cummings, Pharm.D., Departments of Pharmacy and Family Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107.
M.D.
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  • Correction - July 01, 1989

Abstract

Elderly patients with multiple diseases who are receiving diuretics are at risk for renal dysfunction from nonsteroidal anti-inflammatory drugs (NSAIDs). Fifty-two elderly patients (mean age = 72 years, range = 63–87 years) with degenerative joint disease and multiple concomitant illnesses were randomly selected to receive ibuprofen suspension (400 mg) or aspirin (650 mg) 4 times a day. Serum creatinine (Cr), blood urea nitrogen (BUN), weight, and blood pressure were measured at baseline and at weekly intervals for 6 weeks. There were no significant changes from baseline in any tests reflective of renal function, no significant differences between ibuprofen and aspirin, and no influence of concomitant diuretic therapy. Ibuprofen and aspirin administered in the doses examined for 6 weeks appear to have little effect on renal function as measured by serum Cr and BUN in a sample of elderly patients for whom these drugs are commonly employed. Concomitant diuretic therapy does not appear to increase the risk. While these drugs are contraindicated in patients with severe hemodynamic insult, they should not be withheld from elderly patients who require this therapy for analgesic/anti-inflammatory effects because of concern for renal impairment. Further prospective research should be undertaken to clarify levels of patient risk and to define appropriate monitoring in such patients.

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The Journal of the American Board of Family     Practice: 1 (2)
The Journal of the American Board of Family Practice
Vol. 1, Issue 2
1 Apr 1988
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Office-Based Evaluation Of Renal Function In Elderly Patients Receiving Nonsteroidal Anti-Inflammatory Drugs
Doyle M. Cummings, Peter Amadio, Steven Nettler, Michael Freedman
The Journal of the American Board of Family Practice Apr 1988, 1 (2) 77-80; DOI: 10.3122/jabfm.1.2.77

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Office-Based Evaluation Of Renal Function In Elderly Patients Receiving Nonsteroidal Anti-Inflammatory Drugs
Doyle M. Cummings, Peter Amadio, Steven Nettler, Michael Freedman
The Journal of the American Board of Family Practice Apr 1988, 1 (2) 77-80; DOI: 10.3122/jabfm.1.2.77
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