We report an infant with neonatal hyperbilirubinemia due to pyruvate kinase deficiency. The
initial approach involved rapid evaluation, phototherapy, and dose monitoring of serum …

Neonatal hemolytic jaundice is a risk factor for kernicterus. Pyruvate kinase (PK) deficiency
is a rare cause of neonatal hemolytic jaundice, with a prevalence estimated at 1 case per 20 …

Significant hyperbilirubinaemia, anemia, and splenomegaly are common features in patients
with severe haemolysis due to pyruvate kinase (PK) deficiency. Until now, severe neonatal …

Hyperbilirubinemia is one of the most common problems encountered in term newborns.
Historically, management guidelines were derived from studies on bilirubin toxicity in infants …

After RBCs are released from the marrow into the blood, they circulate for about 120 days
before they are culled by the reticuloendothelial system and their constituents recycled. 1 It …

Pyruvate kinase deficiency is a rare cause of congenital hemolytic anemia. Despite a paucity
of reports, splenectomy resulted in successful outcomes for two siblings with this disorder …

1. List the risk factors for severe hyperbilirubinemia. 2. Distinguish between physiologic
jaundice and pathologic jaundice of the newborn. 3. Recognize the clinical manifestations of …

Most newborn infants develop hyperbilirubinemia in the neonatal period. Excessive levels of
hyperbilirubinemia places the infant at risk for bilirubin encephalopathy. We discuss the …

Abstract Case Study Questions* Which one of the following conditions is a complication of
severe neonatal hyperbilirubinemia?* A. Glucose-6-phosphate dehydrogenase deficiency …

Two years after the birth of a first healthy male child, consanguineous parents first cousins)
of Tunisian origin had twin newborns. The delivery occurred spontaneously after 35 weeks …