Presenting signs of multiple myeloma and the effect of diagnostic delay on the prognosis

N Goldschmidt, L Zamir, A Poperno… - The Journal of the …, 2016 - Am Board Family Med
Background: Presenting symptoms of multiple myeloma (MM) are vague and nonspecific.
Early detection poses a diagnostic challenge in primary care. We assessed whether clinical …

Multiple myeloma: causes and consequences of delay in diagnosis

CC Kariyawasan, DA Hughes… - … Journal of Medicine, 2007 - academic.oup.com
Background: Myeloma is a serious and usually fatal haematological malignancy with
reported mortality of 10–20% within the first 2 months of presentation. Symptoms are non …

Time from first symptom onset to the final diagnosis of multiple myeloma (MM)–possible risks and future solutions: retrospective and prospective 'Deutsche …

G Graziani, GW Herget, G Ihorst, M Zeissig… - Leukemia & …, 2020 - Taylor & Francis
Multiple myeloma (MM) often presents with unspecific symptoms and is challenging to
diagnose. We performed this DSMM/EMN-analysis via test-(retro-) and validation …

Interdisciplinary approach to multiple myeloma–time to diagnosis and warning signs

GW Herget, F Kälberer, G Ihorst, G Graziani… - Leukemia & …, 2021 - Taylor & Francis
Delayed diagnosis is a common challenge in the management of multiple myeloma (MM).
This prospective interdisciplinary study evaluated symptoms and time to diagnosis (TTD) in …

Clinical features and diagnosis of multiple myeloma: a population-based cohort study in primary care

A Seesaghur, N Petruski-Ivleva, VL Banks, JR Wang… - BMJ open, 2021 - bmjopen.bmj.com
Objectives Patients with multiple myeloma (MM) experience significant delays in diagnosis
due to non-specific symptomatology. The aim of this study was to characterise the frequency …

Diagnostic delay and complications for older adults with multiple myeloma

CR Friese, GA Abel, LS Magazu, BA Neville… - Leukemia & …, 2009 - Taylor & Francis
Increased attention to timely diagnosis motivated us to study 5483 patients diagnosed with
multiple myeloma using Medicare claims linked to tumor registries in the Surveillance …

[HTML][HTML] Quantifying the risk of multiple myeloma from symptoms reported in primary care patients: a large case–control study using electronic records

EA Shephard, RD Neal, P Rose, FM Walter… - British Journal of …, 2015 - bjgp.org
Background Patients with myeloma experience the longest diagnostic delays compared with
patients with other cancers in the UK; 37% are diagnosed through emergency presentations …

Presenting signs and symptoms in multiple myeloma: high percentages of stage III among patients without apparent myeloma-associated symptoms

F Ong, J Hermans, EM Noordijk, PW Wijermans… - Annals of …, 1995 - Springer
We studied the medical histories of 127 patients diagnosed with multiple myeloma included
in a population-based registry of 945 patients with a paraprotein or multiple myeloma in the …

Common complaints, difficult diagnosis: multiple myeloma

C Dvorak - Journal of the American Association of Nurse …, 2006 - journals.lww.com
Purpose: To review the presenting signs and symptoms of multiple myeloma, its
pathophysiology, diagnostic evaluation, and treatment options. Data sources: A literature …

[HTML][HTML] Multiple myeloma for the primary care provider: a practical review to promote earlier diagnosis among diverse populations

J Mikhael, M Bhutani, CE Cole - The American Journal of Medicine, 2023 - Elsevier
Multiple myeloma is the second most common hematologic malignancy in the United States
and the most common hematologic malignancy among Blacks/African Americans. Delay in …