Purpose: The “card study,” in which clinicians record brief information about patient visits
during usual clinical care, has long been a rapid method for conducting descriptive studies …

For decades, the research community called for streamlined Institutional Review Board (IRB)
review processes for multisite studies. Department of Health and Human Services and …

Background/Aims Obtaining ethical approval from multiple institutional review boards is a
long-standing challenge to multi-site clinical trials and often leads to significant delays in …

Single institutional review board (IRB) review of multisite research increased in frequency
over a decade ago with a proliferation of master IRB reliance agreements supporting …

Effective clinical and translational research is an essential component of improving human
health as delineated in the National Institutes of Health (NIH) roadmap, 1, 2 yet efficiently …

Historically, a single research project involving numerous practice-based research networks
(PBRNs) required multiple institutional review boards (IRBs) to be involved in approval of …

Developing a new Practice-based Research Network (PBRN): lessons learned and challenges
ahead - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …

Purpose In 2014, the National Institutes of Health (NIH) requested public comments on a
draft policy requiring NIH-funded, US-based investigators to use a single institutional review …

Investigators for multisite research studies conducted in practice-based research networks
face numerous challenges associated with Institutional Review Boards (IRBs) and human …

The Trial Innovation Network has established an infrastructure for single IRB review in
response to federal policies. The Network's single IRB (sIRBs) have successfully supported …