Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives
Background: The liver is a well-known player in the metabolism and removal of drugs. Drug
metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the …
metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the …
[HTML][HTML] The role of interferon-gamma and interferon-gamma receptor in tuberculosis and nontuberculous mycobacterial infections
Mycobacterium tuberculosis (Mtb) and nontuberculous mycobacteria (NTM) remain the
leading causes of lung disease and mortality worldwide. Interferon-gamma (IFN-γ) and its …
leading causes of lung disease and mortality worldwide. Interferon-gamma (IFN-γ) and its …
[HTML][HTML] Clinical perspectives of isoniazid-induced liver injury
S Lei, R Gu, X Ma - Liver Research, 2021 - Elsevier
Isoniazid (INH) is a synthetic anti-mycobacterial agent used to treat active or latent
tuberculosis (TB). INH has been in clinical use for nearly 70 years and remains broadly …
tuberculosis (TB). INH has been in clinical use for nearly 70 years and remains broadly …
[HTML][HTML] Advances in diagnostics and drug discovery against resistant and latent tuberculosis infection
C Shleider Carnero Canales, J Marquez Cazorla… - Pharmaceutics, 2023 - mdpi.com
Latent tuberculosis infection (LTBI) represents a subclinical, asymptomatic mycobacterial
state affecting approximately 25% of the global population. The substantial prevalence of …
state affecting approximately 25% of the global population. The substantial prevalence of …
PharmGKB summary: isoniazid pathway, pharmacokinetics
DJ Klein, S Boukouvala, EM McDonagh… - Pharmacogenetics …, 2016 - journals.lww.com
Background Isoniazid [isonicotinic acid (INA) hydrazide, INH; PubChem ID 3767] 1 is a first-
line antimycobacterial agent used to treat active or latent tuberculosis (TB) infections …
line antimycobacterial agent used to treat active or latent tuberculosis (TB) infections …
The microbiome at the pulmonary alveolar niche and its role in Mycobacterium tuberculosis infection
AJ Adami, JL Cervantes - Tuberculosis, 2015 - Elsevier
Advances in next generation sequencing (NGS) technology have provided the tools to
comprehensively and accurately characterize the microbial community in the respiratory …
comprehensively and accurately characterize the microbial community in the respiratory …
PBPK analysis to study the impact of genetic polymorphism of NAT2 on drug-drug interaction potential of isoniazid
A Balhara, S Singh - Pharmaceutical Research, 2021 - Springer
Purpose Isoniazid (INH) is prescribed both for the prophylaxis as well as the treatment of
tuberculosis. It is primarily metabolized through acetylation by a highly polymorphic enzyme …
tuberculosis. It is primarily metabolized through acetylation by a highly polymorphic enzyme …
Latent pseudorabies virus infection in medulla oblongata from quarantined pigs
JJ Lu, WZ Yuan, YP Zhu, SH Hou… - Transboundary and …, 2021 - Wiley Online Library
Pseudorabies virus (PRV) is a major pathogen in pig husbandry and is also a risk to human
well‐being. Pigs with latent PRV infection carry the virus lifelong, and it can be activated …
well‐being. Pigs with latent PRV infection carry the virus lifelong, and it can be activated …
Application of molecular, microbiological, and immunological tests for the diagnosis of bone and joint tuberculosis
Y Tang, L Yin, S Tang, H Zhang… - Journal of clinical …, 2018 - Wiley Online Library
Background To evaluate the application of interferon gamma release assay (IGRA),
rifampicin resistant real‐time fluorescence quantitative PCR technique Xpert Mycobacterium …
rifampicin resistant real‐time fluorescence quantitative PCR technique Xpert Mycobacterium …
[HTML][HTML] Prevalence of latent TB and effectiveness of BCG vaccination against latent tuberculosis: an observational study
B Trollfors, V Sigurdsson… - International Journal of …, 2021 - Elsevier
Objectives This study aimed to determine the prevalence of latent tuberculosis infection
(LTBI) in immigrant children and adolescents (aged 0-17 years) living or recently arriving in …
(LTBI) in immigrant children and adolescents (aged 0-17 years) living or recently arriving in …