Drug‐induced liver injury (DILI) is a major concern for patients, care givers and the
pharmaceutical industry. Interpretation of the serum biomarkers routinely used to detect and …

Children with elevated liver enzymes are occasionally discovered through laboratory work-
up from different clinical scenarios. Although the majority will have transient and/or benign …

Duchenne muscular dystrophy (DMD) is a devastating disorder caused by loss of functional
dystrophin protein, resulting in muscle wasting. Enhancing muscle growth by inhibiting …

Objective In Duchenne muscular dystrophy, creatine kinase and transaminases are
released into the circulation, indicating muscle injury. Their usefulness in monitoring muscle …

Background The frequency of isoniazid hepatotoxicity is low in children receiving isoniazid
therapy for latent tuberculosis infection. However, isoniazid hepatotoxicity may cause liver …

Vector production scale-up is a major barrier in systemic adeno-associated virus (AAV) gene
therapy. Many scalable manufacturing methods have been developed. However, the …

Background and Objectives: Muscle atrophy occurs when protein degradation exceeds
protein synthesis, resulting in imbalanced protein homeostasis, compromised muscle …

Introduction: Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as
biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and …

Introduction Elevated transaminases and/or creatine phosphokinase can indicate underlying
muscle disease. Therefore, this study aims to determine the frequency of Duchenne …

Background: Intestinal failure–associated liver disease (IFALD) is complex and diagnosed
by concurrent use of parenteral nutrition, clinical presentation, and alterations in hepatic …