Many of the drugs currently used in medical practice are mixtures of enantiomers
(racemates). Many a times, the two enantiomers differ in their pharmacokinetic and …

Hypertension is associated with an increased risk of stroke and atherosclerosis. In addition
to elevated blood pressure, hypertension is characterized by neuroendocrine and immune …

The effect of differences in the stereochemistry of drugs on their pharmacokinetic and
pharmacodynamic properties has been recognized for long. In recent years, technological …

There is evidence that fluid retention, whether due to a disease process or due to a
medication, is associated with a number of cardiovascular diseases, including heart failure …

Background: Calcium channel blockers are widely prescribed either as monotherapies or in
combination therapies in the management of hypertension and other cardiovascular …

Macromolecules and water leave the blood microcirculation and bathe the tissues of the
body, and cannot be constitutively reabsorbed by the blood vessels, necessitating an …

Выделяют шесть типов кальциевых каналов, но основное клиническое значе ние
имеют каналы L–и Т–типа. Все при меняемые в настоящее время АК (в том числе и …

Антагонисты кальция являются препаратами выбора при артериальной гипертензии.
Наиболее широкое применение получили дигидропиридиновые антагонисты кальция …

Аннотация Оптически активные стереоизомеры оказались действенным ресурсом для
разработки новых лекарственных средств. При этом S-и R-энантиомеры рацематов …

Technology for the synthesis of S-amlodipine nicotinate drug substance was developed
based on an acceptable method of effective separation of the amlodipine optical isomers. A …