Emerging evidence shows a broad spectrum of biological functions of tissue factor (TF). TF
classical role in initiating the extrinsic blood coagulation and its direct thrombotic action in …

Introduction 3. Role of TF-initiated blood coagulation in thrombosis 4. Direct contribution to
thrombogenesis 4.1. Fibrin" thrombosis 4.2. Anti-fibrinolytic relevance 4.3. Platelet …

Currently, the established risk factors for cardiovascular disease (CVD) are largely
environmental in nature. Conflicting studies have suggested that mutations in specific …

Background Activated protein C resistance (APCR) due to factor V Leiden (FVL) mutation
(R506Q) is a major risk factor in patients with venous thromboembolism (VTE). The present …

Thrombosis is one of the leading cause of death, globally, anticardiolipin antibodies (aCL)
has been implicated as one of the most common acquired protein defect causing …

Protein C (PC) is a major anticoagulant that stems the propagation of thrombin. The
activated form of PC (APC), in association with the cofactor protein S, proteolytically converts …

Background Deep venous thrombosis (DVT) usually affects patients who are over 40 years
old, obese, bed ridden or have had major operations or have hypercoagulable states …

INTRODUCTION: Activated protein C (APC) is well-established as a physiologically
important anticoagulant. During development, plasma concentrations of protein C and …

Resistance to activated protein C determined by factor V Leiden (FVL) is the most frequent
inherited risk factor of venous thrombosis. The purpose of our work was to reveal the …

Activated protein C (APC) generation strongly affects sepsis and thrombosis by inhibition of
thrombin generation. However, it is unclear if there are age-related differences in …