ContextHypertensive patients are often given a calcium antagonist to reduce cardiovascular
disease risk, but the benefit compared with other drug classes is controversial.ObjectiveTo …

X-ray crystallography provides the vast majority of macromolecular structures, but the success
of the method relies on growing crystals of sufficient size. In conventional measurements, …

… The hypothesis that this is a true network degeneration would predict involvement of the
white matter tracts connecting these structures (ie parahippocampal white matter, posterior …

G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin
binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-…

X-ray crystallography of G protein–coupled receptors and other membrane proteins is hampered
by difficulties associated with growing sufficiently large crystals that withstand radiation …

Intense femtosecond x-ray pulses produced at the Linac Coherent Light Source (LCLS) were
used for simultaneous x-ray diffraction (XRD) and x-ray emission spectroscopy (XES) of …

The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host
protein degradation, is a promising target to develop new treatments against sleeping …

Blood pressure (BP) control rates around the world are suboptimal. Part 2 of the National
Health and Nutrition Educational Survey (NHANES) III indicates that only 27.4% of …

Photosynthesis, a process catalysed by plants, algae and cyanobacteria converts sunlight
to energy thus sustaining all higher life on Earth. Two large membrane protein complexes, …

Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …