Impact of long‐term complications on quality of life in patients with type 2 diabetes not using insulin

A Lloyd, W Sawyer, P Hopkinson - Value in Health, 2001 - Wiley Online Library
Objectives: The complications of diabetes have the potential to greatly impact the health‐related
quality of life (HRQOL) of patients with type 2 diabetes. The effect of diabetic …

How much ritonavir is needed to boost protease inhibitors? Systematic review of 17 dose-ranging pharmacokinetic trials

A Hill, J van der Lugt, W Sawyer, M Boffito - Aids, 2009 - journals.lww.com
Background: Ritonavir has been evaluated at boosting doses of 50–800 mg daily with seven
protease inhibitors: amprenavir, atazanavir, darunavir, indinavir, lopinavir, saquinavir and …

Pharmacokinetics and pharmacodynamics of recombinant factor VIIa

CM Lindley, WT Sawyer, BG Macik… - Clinical …, 1994 - Wiley Online Library
Objective To evaluate the pharmacokinetics and pharmacodynamics of recombinant activated
factor VII (rFVIIa). Methods Single‐dose pharmacokinetics of three dose levels (17.5, 35, …

Depth-dependent flourescent quenching in micelles and membranes

E Blatt, WH Sawyer - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1985 - Elsevier
… The main assumption is that Io/I at a particular quencher concentration will only be dependent
on (Q), and will be independent of the quenching mechanism, the quenching efficiency or …

Antibody-mediated delivery of chimeric BRD4 degraders. Part 2: improvement of in vitro antiproliferation activity and in vivo antitumor efficacy

…, A O'Donohue, RK Rowntree, WS Sawyer… - Journal of Medicinal …, 2021 - ACS Publications
Heterobifunctional compounds that direct the ubiquitination of intracellular proteins in a
targeted manner via co-opted ubiquitin ligases have enormous potential to transform the field of …

[HTML][HTML] Treatment characteristics and real-world progression-free survival in patients with unresectable stage III NSCLC who received durvalumab after …

…, B Markman, TJN Hiltermann, A Taus, W Sawyer… - Journal of Thoracic …, 2023 - Elsevier
Introduction The phase 3 PACIFIC trial established consolidation therapy with durvalumab
as standard of care for patients with unresectable, stage III NSCLC and no disease …

Spectral properties of fluorescein in solvent‐water mixtures: applications as a probe of hydrogen bonding environments in biological systems

…, EW Voss Jr, WH Sawyer - Photochemistry and …, 1998 - Wiley Online Library
Although fluorescein is a widely used fluorescent probe in the biosciences, the effect of solvent
environment on its spectral properties is poorly understood. In this paper we explore the …

[12] Fluorescence anisotropy applied to biomolecular interactions

DM Jameson, WH Sawyer - Methods in enzymology, 1995 - Elsevier
Publisher Summary This chapter focuses on the applications of polarization or anisotropy
data. The appeal of fluorescence spectroscopy in the study of biomolecular systems lies in the …

Patterns and determinants of intra-industry trade in Asia

WC Sawyer, RL Sprinkle, K Tochkov - Journal of Asian Economics, 2010 - Elsevier
Intra-industry trade (IIT) has gained in importance across Asia as a result of the rapid growth
of Asian economies and their key role in the international fragmentation of production. This …

An experimental analysis of the food location behavior of frugivorous bats

TH Fleming, ER Heithaus, WB Sawyer - Ecology, 1977 - Wiley Online Library
… We predict that bats will search for these species while commut… We predict that bats will
not search for these fruits while … We predict that bats will not search for these fruits while …