Human endurance performance can be predicted from maximal oxygen consumption (V̇o
2max ), lactate threshold, and exercise efficiency. These physiological parameters, however, …

The combination of living at altitude and training near sea level [live high–train low (LHTL)]
may improve performance of endurance athletes. However, to date, no study can rule out a …

Recent experimental studies and one clinical case have suggested that grafting tissue from
the adrenal medulla into the brain may ameliorate the signs of Parkinson's disease. We …

Background Type 2 diabetes presents a major morbidity and mortality burden in the United
States. Diabetes self-management education (DSME) is an intervention associated with …

We present a single-field string inflationary model which allows for the generation of primordial
black holes in the low mass region where they can account for a significant fraction of the …

The transcriptional factor Snail1 is a repressor of E-cadherin (CDH1) gene expression
essential for triggering epithelial-mesenchymal transition. Snail1 represses CDH1, directly …

F-box proteins are the key recognition subunit of multimeric E3 ubiquitin ligase complexes
that participate in the proteasome degradation of specific substrates. In the last years, a …

Chemical descriptors encode the physicochemical and structural properties of small molecules,
and they are at the core of chemoinformatics. The broad release of bioactivity data has …

These findings show that inhibition of USP27X destabilizes Snail1 to impair EMT and renders
tumor cells sensitive to chemotherapy, thus opening new strategies for the inhibition of …

The zinc finger transcription factor Snail1 regulates epithelial to mesenchymal transition,
repressing epithelial markers and activating mesenchymal genes. Snail1 is an extremely labile …