The transcriptional factor Snail1 is a repressor of E-cadherin (CDH1) gene expression
essential for triggering epithelial-mesenchymal transition. Snail1 represses CDH1, directly …

We present a single-field string inflationary model which allows for the generation of primordial
black holes in the low mass region where they can account for a significant fraction of the …

F-box proteins are the key recognition subunit of multimeric E3 ubiquitin ligase complexes
that participate in the proteasome degradation of specific substrates. In the last years, a …

Chemical descriptors encode the physicochemical and structural properties of small molecules,
and they are at the core of chemoinformatics. The broad release of bioactivity data has …

These findings show that inhibition of USP27X destabilizes Snail1 to impair EMT and renders
tumor cells sensitive to chemotherapy, thus opening new strategies for the inhibition of …

The transcription factor SNAIL1 is a master regulator of epithelial to mesenchymal transition.
SNAIL1 is a very unstable protein, and its levels are regulated by the E3 ubiquitin ligase β-…

The zinc finger transcription factor Snail1 regulates epithelial to mesenchymal transition,
repressing epithelial markers and activating mesenchymal genes. Snail1 is an extremely labile …

Methylation of histone H3 lysine 4 is linked to active transcription and can be removed by
LSD 1 or the JmjC domain‐containing proteins by amino‐oxidation or hydroxylation, …

UEV proteins are enzymatically inactive variants of the E2 ubiquitin-conjugating enzymes
that regulate noncanonical elongation of ubiquitin chains. In Saccharomyces cerevisiae, UEV …

Background : Limited data exist about safety and efficacy of transcatheter aortic valve
replacement (TAVR) in patients with pure native aortic regurgitation (AR). Objectives : This study …