Background: Vitamin D and calcium deficiencies are common worldwide, causing nutritional
rickets and osteomalacia, which have a major impact on health, growth, and development …

… serum level of 25(OH) D is measured to determine the adequacy of vitamin D status. In the
kidney, 25(OH)D is hydroxylated to 1,25-dihydroxyvitamin D [1,25(OH) 2 D], which is the only …

Background Hypophosphatasia results from mutations in the gene for the tissue-nonspecific
isozyme of alkaline phosphatase (TNSALP). Inorganic pyrophosphate accumulates …

Introduction: Nutritional rickets has been described from at least 59 countries in the last 20
years. Its spectrum of causes differs in different regions of the world. Methods: We conducted …

Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory
illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many …

Background Nutritional rickets remains prevalent in many tropical countries despite the fact
that such countries have ample sunlight. Some postulate that a deficiency of dietary calcium, …

Radiographic changes of rickets are well characterized, but no method of grading the
severity of these changes has been in general use. Consequently, it is difficult to compare …

We have conducted a pragmatic clinical trial aimed to assess whether an electrocardiogram
(ECG)-based, artificial intelligence (AI)-powered clinical decision support tool enables early …

Objective: Because the causes of nutritional rickets in tropical countries are poorly
understood, we conducted a case-control study to determine factors associated with rickets in …

… *Address all correspondence and requests for reprints to: Tom D. Thacher, MD, Department
of Family Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905. …