Measurements of hepatic iron concentration (HIC) are important predictors of transfusional
iron burden and long-term outcome in patients with transfusion-dependent anemias. The goal …

Although sickle cell disease (SCD) is marked by high utilization of medical resources, the
full cost of care for patients with SCD, including care not directly related to SCD, is unknown. …

Cardiac T2* (magnetic resonance imaging relaxation parameter) is abnormally low in
approximately 40% of adults with thalassemia major (TM), suggesting myocardial iron deposition, …

BACKGROUND: Patients with thalassemia major require iron chelation therapy (ICT) to
prevent complications from transfusional iron overload. Deferoxamine is effective, but requires …

Background— Transfusional therapy for thalassemia major and sickle cell disease can lead
to iron deposition and damage to the heart, liver, and endocrine organs. Iron causes the MRI …

High hepatic iron concentration (HIC) is associated with cardiac iron overload. However,
simultaneous measurements of heart and liver iron often demonstrate no significant linear …

Iron cardiomyopathy remains the leading cause of death in patients with thalassemia major.
Magnetic resonance imaging (MRI) is ideally suited for monitoring thalassemia patients …

Diabetes mellitus and cardiomyopathy are common in chronically transfused thalassemia
major patients, occurring in the second and third decades of life. We postulated that pancreatic …

Iron overload and iron toxicity, whether because of increased absorption or iron loading
from repeated transfusions, can be major causes of morbidity and mortality in a number of …

Purpose To optimize R2*(1/T2*) measurements for cardiac iron detection in sickle cell and
thalassemia patients. Materials and Methods We studied 31 patients with transfusion‐…