Background Recent randomized clinical trials have suggested that estrogen plus progestin
does not confer cardiac protection and may increase the risk of coronary heart disease (CHD)…

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Objective. —To review the scientific evidence concerning the safety and efficacy of various
antihypertensive therapies used as first-line agents and evaluated in terms of major disease …

Objective. —To assess the association between first myocardial infarction and the use of
antihypertensive agents. Design and Setting. —We conducted a population-based case-control …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Several studies suggest that inflammation plays a role in the pathogenesis of some glucose
disorders in adults. We tested this hypothesis in a longitudinal cohort study of older …

PURPOSE: To determine the incidence of deep vein thrombosis and pulmonary embolism
in two cohorts representing regions of the United States. METHODS: The sample comprised …

Background Limited information is available regarding genetic contributions to valvular
calcification, which is an important precursor of clinical valve disease. Methods We determined …

Background The association between traditional cardiovascular risk factors and risk of
venous thromboembolism (VTE) has not been extensively examined in prospective studies. …