The vanilloid receptor VR1 is a nonselective cation channel that is most abundant in peripheral
sensory fibers but also is found in several brain nuclei. VR1 is gated by protons, heat, …

Synthetic cannabinoids produce behavioral analgesia and suppress pain neurotransmission,
raising the possibility that endogenous cannabinoids serve naturally to modulate pain. …

N-Arachidonoyldopamine (NADA) was recently identified as an endogenous ligand for the
vanilloid type 1 receptor (VR1). Further analysis of the bovine striatal extract from which …

In mammals, specific lipids and amino acids serve as crucial signaling molecules. In bacteria,
conjugates of lipids and amino acids (referred to as lipoamino acids) have been identified …

A plethora of growth factors regulate keratinocyte proliferation and differentiation that control
hair morphogenesis and skin barrier formation. Wavy hair phenotypes in mice result from …

During the last decade, rigorous scientific methods have been applied to determine the effects
of cannabinoids on nociceptive neurotransmission. Cannabinoids have been observed to …

Burning of Boswellia resin as incense has been part of religious and cultural ceremonies for
millennia and is believed to contribute to the spiritual exaltation associated with such events…

The ability to sense changes in the environment is essential for survival because it permits
responses such as withdrawal from noxious stimuli and regulation of body temperature. …

Background: The discovery of heat-sensitive Transient Receptor Potential Vanilloid (TRPV)
ion channels provided a potential molecular explanation for the perception of innocuous and …

The discovery of cannabinoid receptors and their putative endogenous ligands raises questions
as to the nature of the effects produced by cannabinoids on neural circuits that mediate …