User profiles for Steven Lin
 | Steven LinAssistant Research Fellow, Institute of Biological Chemistry, Academia Sinica, Taiwan Verified email at gate.sinica.edu.tw Cited by 10190 |
Real-time DNA sequencing from single polymerase molecules
…, D Holden, G Kearns, X Kong, R Kuse, Y Lacroix, S Lin… - Science, 2009 - science.org
We present single-molecule, real-time sequencing data obtained from a DNA polymerase
performing uninterrupted template-directed synthesis using four distinguishable fluorescently …
performing uninterrupted template-directed synthesis using four distinguishable fluorescently …
RNA-programmed genome editing in human cells
10.7554/eLife.00471.001 Type II CRISPR immune systems in bacteria use a dual RNA-guided
DNA endonuclease, Cas9, to cleave foreign DNA at specific sites. We show here that …
DNA endonuclease, Cas9, to cleave foreign DNA at specific sites. We show here that …
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
V Pattanayak, S Lin, JP Guilinger, E Ma… - Nature …, 2013 - nature.com
The RNA-programmable Cas9 endonuclease cleaves double-stranded DNA at sites
complementary to a 20-base-pair guide RNA. The Cas9 system has been used to modify genomes …
complementary to a 20-base-pair guide RNA. The Cas9 system has been used to modify genomes …
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
Introduction Bacteria and archaea defend themselves against invasive DNA using adaptive
immune systems comprising CRISPR (clustered regularly interspaced short palindromic …
immune systems comprising CRISPR (clustered regularly interspaced short palindromic …
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
10.7554/eLife.04766.001 The CRISPR/Cas9 system is a robust genome editing technology
that works in human cells, animals and plants based on the RNA-programmed DNA cleaving …
that works in human cells, animals and plants based on the RNA-programmed DNA cleaving …
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor
GA Donzella, D Schols, SW Lin, JA Esté… - Nature medicine, 1998 - nature.com
The bicyclam AMD3100 (formula weight 830) blocks HIV-1 entry and membrane fusion via
the CXCR4 co-receptor, but not via CCR5. AMD3100 prevents monoclonal antibody 12G5 …
the CXCR4 co-receptor, but not via CCR5. AMD3100 prevents monoclonal antibody 12G5 …
Routing lookups in hardware at memory access speeds
The increased bandwidth in the Internet puts great demands on network routers; for example,
to route minimum sized Gigabit Ethernet packets, an IP router must process about 1.5/spl …
to route minimum sized Gigabit Ethernet packets, an IP router must process about 1.5/spl …
Integrating genomic features for non-invasive early lung cancer detection
…, PP Massion, AS Mansfield, J Jen, HZ Ren, SH Lin… - Nature, 2020 - nature.com
Radiologic screening of high-risk adults reduces lung-cancer-related mortality 1 , 2 ; however,
a small minority of eligible individuals undergo such screening in the United States 3 , 4 . …
a small minority of eligible individuals undergo such screening in the United States 3 , 4 . …
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
K Schumann, S Lin, E Boyer… - Proceedings of the …, 2015 - National Acad Sciences
T-cell genome engineering holds great promise for cell-based therapies for cancer, HIV,
primary immune deficiencies, and autoimmune diseases, but genetic manipulation of human T …
primary immune deficiencies, and autoimmune diseases, but genetic manipulation of human T …
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
Ferroptosis, a form of regulated cell death caused by lipid peroxidation, was recently identified
as a natural tumor suppression mechanism. Here, we show that ionizing radiation (IR) …
as a natural tumor suppression mechanism. Here, we show that ionizing radiation (IR) …