… In PG lesions, there also seems to be a T H 17 cell–regulatory T (T reg ) cell imbalance,
hallmarked by a reduction in T reg cells and concurrent overexpression of T H 17 cell-associated …

Background Alopecia areata (AA) is an immune-mediated disease resulting in nonscarring
hair loss. Systematic reviews on the psychosocial and psychiatric comorbidities, health-…

Psoriatic arthritis (PsA) is a large volume of our clinical practice and its management can be
challenging. Traditional DMARDs have been used over last six decades and observational …

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a posttranslational regulator of the
LDL receptor (LDLR). Recent studies have proposed a role for PCSK9 in regulating immune …

Psoriasis (PsO) and psoriatic arthritis (PsA) are chronic immune-mediated inflammatory
diseases of multifactorial etiology. In addition to genetic and environmental factors, evidence …

Importance Generalized pustular psoriasis (GPP) is a chronic, orphan disease with limited
epidemiological data. Objective To describe the clinical characteristics, treatments, …

Alterations in the human glycome have been associated with cancer and autoimmunity.
Thus, constructing a site-specific map of the human glycome for biomarker research and …

The present paradigm of psoriasis pathogenesis revolves around the IL-23/IL-17A axis. Dual-secreting
Th17 T cells presumably are the predominant sources of the psoriasis phenotype-…

Pemphigus vulgaris (PV) is a chronic autoimmune disorder that is frequently refractory and
prone to relapse despite immunosuppressive therapy. Although IgG4 autoantibodies to …

DISCUSSION The presence of positivity for CD4, CD56, and multiple plasmacytoid dendritic
cell (pDC) markers (CD123, TCL1A, TCF4, BCL2) on immunohistochemistry was consistent …