The coi1 mutation defines an Arabidopsis gene required for response to jasmonates, which
regulate defense against insects and pathogens, wound healing, and pollen fertility. The wild…

Background Precision medicine approaches that target patients on the basis of disease
subtype have transformed treatment approaches to cancer, asthma, and other heterogeneous …

Perforated marine gastropod shells at the western Asian site of Skhul and the North African
site of Oued Djebbana indicate the early use of beads by modern humans in these regions. …

The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants jeopardizes the protective antiviral immunity induced after infection or …

We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated
immunity to antigenically variable pathogens, achieved by accounting for antigenic …

Avian A/H5N1 influenza viruses pose a pandemic threat. As few as five amino acid
substitutions, or four with reassortment, might be sufficient for mammal-to-mammal transmission …

Background Functional capacity is an important component of risk assessment for major
surgery. Doctors' clinical subjective assessment of patients' functional capacity has uncertain …

Liver disease is one of the leading causes of death worldwide 1 . Patients with cirrhosis
display an increased predisposition to and mortality from infection due to multimodal defects in …

Scholars and pundits alike argue that US scientists could do more to reach out to the general
public. Yet, to date, there have been few systematic studies that examine how scientists …

Background Midlife hypertension confers increased risk for cognitive impairment in late life.
The sensitive period for risk exposure and extent that risk is mediated through amyloid or …