Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Myocardial infarction (MI), a leading cause of death around the world, displays a complex
pattern of inheritance 1 , 2 . When MI occurs early in life, genetic inheritance is a major …

The number and volume of cells in the blood affect a wide range of disorders including cancer
and cardiovascular, metabolic, infectious and immune conditions. We consider here the …

Atherosclerotic cardiovascular disease results in >19 million deaths annually, and coronary
heart disease accounts for the majority of this toll. Despite major advances in treatment of …

Background Coronary calcium identified by electron-beam computed tomography (EBCT)
correlates poorly with luminal atherosclerotic narrowing, but calcium, an intimate part of …

Restenosis is a reparative response to arterial injury occurring with percutaneous coronary
revascularization. However, the quantitative characteristics of the relation between vessel …

Background With the thrombogenic tendency and permanent implant nature of metallic stents,
synthetic polymers have been proposed as candidate materials for stents and local drug …

Objectives. This study was designed to evaluate whether calcium deposition in the coronary
arteries is related to atherosclerotic plaque burden and narrowing of the arterial lumen. …

Context Coronary computed tomographic (CT) angiography is a noninvasive anatomic test
for diagnosis of coronary stenosis that does not determine whether a stenosis causes …

Background—Despite the increasing use of stents, few reports have described human
coronary artery morphology early and late after stenting. Methods and Results—Histology was …