Background Combination therapy with angiotensin-converting–enzyme (ACE) inhibitors and
angiotensin-receptor blockers (ARBs) decreases proteinuria; however, its safety and effect …

Optimal cellular function is dependent on maintenance of a normal serum phosphorus
concentration. Serum phosphorus concentration is affected by several determinants, the most …

The distal tubule of the mammalian kidney, defined as the region between the macula
densa and the collecting duct, is morphologically and functionally heterogeneous. This …

Gadolinium chelates are commonly used to improve tissue contrast in MRI. Until recently
the use of gadolinium was thought to be risk-free compared with alternative contrast agents. …

Predictors of hyperkalemia in patients with cardiovascular disease (CVD; defined as patients
with hypertension and heart failure) and associated chronic kidney disease (CKD) are not …

Mineralocorticoid hormones regulate salt transport along the distal nephron by binding to
intracellular receptors and activating gene transcription. Previous experiments showed that …

We have analyzed the regulatory properties of the wild-type cardiac Na(+)-Ca2+ exchanger
expressed in Xenopus laevis oocytes using the giant excised patch technique. The …

We have recently isolated cDNAs encoding a Na(+)-H+ exchanger isoform, referred to as
NHE-1, from rabbit kidney and LLC-PK1 cells. To identify the NHE-1 protein and to establish its …

Rhabdomyolysis is a common clinical syndrome and accounts for 7% of all cases of acute
kidney injury (AKI) in the USA. It can result from a wide variety of disorders, such as trauma, …

Results Mean age was 43±10 years, 56% of participants were women, and 52% were
African American. BP was higher in African Americans than in non–African Americans, 131/81±20/…