Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening,
immunologically mediated, and usually drug-induced disease with a high burden to individuals, …

… bodies against TCR+CD2 surface complexes (Cibotti nih.gov). … Cibotti et al., 1997). We
performed 40 cycles of PCR (Taq DNA polymerase kit, GIBCO–BRL) of which each cycle …

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening,
immune-mediated adverse reactions characterized by widespread erythema, …

We have previously produced a transgenic mouse line for hen egg lysozyme (HEL), an
experimental model for analyzing tolerance to self-antigens at the peptide level. We have now …

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a predominantly drug-induced
disease, with a mortality rate of 15–20%, that engages the expertise of multiple …

We have produced transgenic mice expression hen egg-white lysozyme (HEL) under the
control of a ubiquitous promoter, so that in transgenic animals, HEL is presumably present in …

Increased Type I IFNs or IFN-I have been associated with human systemic lupus erythematosus.
Interestingly augmenting or negating IFN-I activity in murine lupus not only modulates …

Differentiation of immature double positive (DP) CD4 + CD8 + thymocytes into single positive
(SP) CD4 + and CD8 + T cells is referred to as positive selection and requires physical …

A coordinated effort combining bioinformatic tools with high-throughput cell-based screening
assays was implemented to identify novel factors involved in T-cell biology. We generated …

Background: Little is known about the burden of atopic dermatitis (AD) encountered in US
primary care practices and the frequency and type of skin care practices routinely used in …