The past two years have seen an explosion in the structural understanding of the endosomal
sorting complex required for transport (ESCRT) machinery that facilitates the trafficking of …

Genetic mutations cause primary immunodeficiencies (PIDs) that predispose to infections.
Here, we describe activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-…

To examine the effectiveness of interventions aimed at improving physical activity, diet, and/or
weight-related behaviors amongst university/college students. Five online databases were …

There is a simple robust variance estimator for cluster-correlated data. While this estimator
is well known, it is poorly documented, and its wide range of applicability is often not …

Embryonic stem (ES) cells, the totipotent outgrowths of bias-tocysts 1,2 , can be cultured and
manipulated in vitro and then returned to the embryonic environment where they develop …

… In three studies of the EEG sleep of young men and women (Williams, Webb, & Agnew,
1964, 1965) we have accumulated and scored 43 records from the first night in a series of four …

Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but
the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to …

The specific phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 have
been invaluable tools for elucidating the roles of these enzymes in signal transduction …

The crystal structure of a ternary complex of human immunodeficiency virus type 1 reverse
transcriptase (HIV-1 RT) heterodimer (p66/p51), a 19-base/18-base double-stranded DNA …

Background Use of heterologous prime-boost COVID-19 vaccine schedules could facilitate
mass COVID-19 immunisation. However, we have previously reported that heterologous …