The ends of human chromosomes are constituted of telomeres, a nucleoprotein complex.
They are mainly formed by the entanglement of repeat DNA and telomeric and non-telomeric …

Ligation‐mediated PCR was employed to quantify cyclobutane pyrimidine dimer (CPD)
formation at nucleotide resolution along exon 2 of the adenine phosphoribosyltransferase (aprt) …

The biological concept of microchimerism, the bidirectional trafficking and stable long-term
persistence of small numbers of allogeneic (fetal and maternal) cells in a genetically different …

Adaptor protein (AP) complexes regulate clathrin-coated vesicle assembly, protein cargo
sorting, and vesicular trafficking between organelles in eukaryotic cells. Because disruption of …

P53 is a master transcriptional regulator controlling several main cellular pathways. Its role
is to adapt gene expression programs in order to maintain cellular homeostasis and genome …

During certain types of cellular stress, the p53 tumor suppressor protein binds to DNA and
transactivates a variety of genes that regulate critical responses including apoptosis, cell cycle …

Fabry disease is a complex, multisystemic and clinically heterogeneous disease, in which
the urinary excretion of globotriaosylceramide (Gb 3 ), the principal substrate of the deficient …

We have used the recently developed technique of differential display polymerase chain
reaction to seek for new genes modulated by tumor necrosis factor-α (TNF-α) in cultured …

The ultraviolet (UV) component of sunlight is the main cause of skin cancer. More than 50%
of all non-melanoma skin cancers and >90% of squamous cell carcinomas in the US carry a …

Werner syndrome is a rare disorder characterized by the premature onset of a number of
age-related diseases. The gene responsible for Werner syndrome encodes a DNA helicase/…