Cytochromes P450 (P450s) metabolize a wide range of endogenous compounds and
xenobiotics, such as pollutants, environmental compounds, and drug molecules. The microsomal, …

The recent discovery of IsPETase, a hydrolytic enzyme that can deconstruct poly(ethylene
terephthalate) (PET), has sparked great interest in biocatalytic approaches to recycle plastics. …

Inhibitors of the molecular chaperone heat shock protein 90 (Hsp90) are currently
generating significant interest in clinical development as potential treatments for cancer. In a …

… Day Philip Day is Reader in Quantitative Analytical Genomics and Synthetic Biology,
Manchester University, Philip leads interdisciplinary research for developing innovative tools in …

The skin offers a perfect model system for studying the wound healing cascade, which
involves a finely tuned interplay between several cell types, pathways and processes. The …

Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR)
reveal a lack of transparent and comprehensive reporting of essential technical …

This monograph addresses developmental education in the 21st Century, identifying the major
issues and providing examples of successful developmental programs. The first chapter, "…

The cyclin D1–cyclin-dependent kinase 4 (CDK4) complex is a key regulator of the transition
through the G 1 phase of the cell cycle. Among the cyclin/CDKs, CDK4 and cyclin D1 are …

The protein Keap1 is central to the regulation of the Nrf2-mediated cytoprotective response,
and is increasingly recognized as an important target for therapeutic intervention in a range …

Background. Zidovudine is recommended for asymptomatic and early symptomatic human
immunodeficiency virus (HIV) infection. The best time to initiate zidovudine treatment remains …