… Progress has been made towards reducing the 85% of wasted effort in medical research—and
the huge amounts of money misspent and harm caused to patients—but there’s still a long …

Without a complete published description of interventions, clinicians and patients cannot
reliably implement interventions that are shown to be useful, and other researchers cannot …

This article deals with inconsistency of relative (rather than absolute) treatment effects in
binary/dichotomous outcomes. A body of evidence is not rated up in quality if studies yield …

Although randomised trials are widely accepted as the ideal way of obtaining unbiased
estimates of treatment effects, some treatments have dramatic effects that are highly unlikely to …

This article is the first of a series providing guidance for use of the Grading of Recommendations
Assessment, Development, and Evaluation (GRADE) system of rating quality of …

Background To comprehend the results of diagnostic accuracy studies, readers must understand
the design, conduct, analysis, and results of such studies. That goal can be achieved …

Incomplete reporting has been identified as a major source of avoidable waste in biomedical
research. Essential information is often not provided in study reports, impeding the …

The quality of reporting of studies of diagnostic accuracy is less than optimal. Complete and
accurate reporting is necessary to enable readers to assess the potential for bias in the …

Without accessible and usable reports, research cannot help patients and their clinicians. In
a published Personal View, 1 a medical researcher with myeloma reflected on the way that …

BACKGROUND AND OBJECTIVE: Overdiagnosis and underdiagnosis of attention-deficit/hyperactivity
disorder (ADHD) are widely debated, fueled by variations in prevalence estimates …