ALK‐positive anaplastic large‐cell lymphoma (ALCL) has been recognized as a distinct
type of lymphoma in the heterogeneous group of T/Null‐ALCL. While most of the ALK‐positive …

Endometrial stromal tumors are divided into three types: benign stromal nodules, endometrial
stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of cytogenetic …

Background Cell viability and motility comprise ubiquitous mechanisms involved in a variety
of (patho)biological processes including cancer. We report a technical comparative analysis …

Reduction of epithelial cell–cell adhesion via the transcriptional repression of cadherins in
combination with the acquisition of mesenchymal properties are key determinants of epithelial…

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the
gastrointestinal tract. KIT and PDGFRA activating mutations are the oncogenic mechanisms in …

A striking feature of Ewing sarcoma is the presence of blood lakes lined by tumor cells. The
significance of these structures, if any, is unknown. Here, we report that the extent of blood …

The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of
transcription factors that play a complex and essential role in the regulation of physiologic cell …

In non-small cell lung cancer, epidermal growth factor receptor gene mutations and anaplastic
lymphoma kinase (ALK) gene rearrangements have a major impact upon the level of …

Rearrangements of the ROS1 gene occur in 1–2 % of non-small cell lung cancers (NSCLCs).
Crizotinib, a highly effective inhibitor of ROS1 kinase activity, is now FDA-approved for the …

Background Secretory GTPases like Rab27B control vesicle exocytosis and deliver critical
proinvasive growth regulators into the tumor microenvironment. The expression and role of …