Background Recent randomized clinical trials have suggested that estrogen plus progestin
does not confer cardiac protection and may increase the risk of coronary heart disease (CHD)…

Background The efficacy of calcium with vitamin D supplementation for preventing hip and
other fractures in healthy postmenopausal women remains equivocal. Methods We recruited …

ContextMultiple epidemiologic studies and some trials have linked diet with cardiovascular
disease (CVD) prevention, but long-term intervention data are needed.ObjectiveTo test the …

Background Higher intake of calcium and vitamin D has been associated with a reduced risk
of colorectal cancer in epidemiologic studies and polyp recurrence in polyp-prevention trials…

ContextThe hypothesis that a low-fat dietary pattern can reduce breast cancer risk has existed
for decades but has never been tested in a controlled intervention trial.ObjectiveTo assess …

Objective. —To test the short-term feasibility and efficacy of seven nonpharmacologic
interventions in persons with high normal diastolic blood pressure. Design. —Randomized control …

ContextObservational studies and polyp recurrence trials are not conclusive regarding the
effects of a low-fat dietary pattern on risk of colorectal cancer, necessitating a primary …

Little is known about the patterns of treatment and adequacy of blood pressure control in
older women. The Women’s Health Initiative, a 40-center national study of risk factors and …

Behavior pattern was assessed by interview for 3,110 men at eight centers in the Multiple Risk
Factor Intervention Trial (1973–1976). The Type A pattern was not significantly associated …

Objective. Diets reduced in fat and cholesterol are recommended for children over 2 years
of age, yet long-term safety and efficacy are unknown. This study tests the long-term efficacy …