Statin toxicity: mechanistic insights and clinical implications
NC Ward, GF Watts, RH Eckel - Circulation research, 2019 - Am Heart Assoc
There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein
cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs …
cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs …
Oxidative stress in human hypertension: association with antihypertensive treatment, gender, nutrition, and lifestyle
NC Ward, JM Hodgson, IB Puddey, TA Mori… - Free Radical Biology …, 2004 - Elsevier
There is growing evidence that oxidative stress contributes to the pathogenesis of hypertension.
Our aim was to measure markers of oxidative stress in hypertensive subjects, and …
Our aim was to measure markers of oxidative stress in hypertensive subjects, and …
Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial
…, X Yang, KD Croft, MJ Considine, NC Ward… - Free Radical Biology …, 2012 - Elsevier
Flavonoids and nitrates in fruits and vegetables may protect against cardiovascular disease.
Dietary flavonoids and nitrates can augment nitric oxide status via distinct pathways, which …
Dietary flavonoids and nitrates can augment nitric oxide status via distinct pathways, which …
Codon optimization of human factor VIII cDNAs leads to high-level expression
NJ Ward, SMK Buckley, SN Waddington… - Blood, The Journal …, 2011 - ashpublications.org
Gene therapy for hemophilia A would be facilitated by development of smaller expression
cassettes encoding factor VIII (FVIII), which demonstrate improved biosynthesis and/or …
cassettes encoding factor VIII (FVIII), which demonstrate improved biosynthesis and/or …
[HTML][HTML] Stable gene transfer to muscle using non-integrating lentiviral vectors
L Apolonia, SN Waddington, C Fernandes, NJ Ward… - Molecular Therapy, 2007 - cell.com
Human immunodeficiency virus (HIV)-based lentiviral vectors (LVs) hold immense promise
for gene delivery applications because of their relatively large packaging capacity and their …
for gene delivery applications because of their relatively large packaging capacity and their …
SGLT2 inhibitor–induced sympathoinhibition: a novel mechanism for cardiorenal protection
…, C Rudnicka, J Hricova, R Carnagarin, NC Ward… - Basic to Translational …, 2020 - jacc.org
Recent clinical trial data suggest a cardiorenal protective effect of sodium glucose
cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical denervation in neurogenic …
cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical denervation in neurogenic …
Effects of tea and coffee on cardiovascular disease risk
Tea and coffee have been associated with risk of cardiovascular disease (CVD), both positively
and negatively. Epidemiological data suggest that black and green tea may reduce the …
and negatively. Epidemiological data suggest that black and green tea may reduce the …
Quality control guidelines for clinical-grade human induced pluripotent stem cell lines
…, H Stachelscheid, SR Velayudhan, NJ Ward… - Regenerative …, 2018 - Future Medicine
Use of clinical-grade human induced pluripotent stem cell (iPSC) lines as a starting material
for the generation of cellular therapeutics requires demonstration of comparability of lines …
for the generation of cellular therapeutics requires demonstration of comparability of lines …
[HTML][HTML] Quickly finding orthologs as reciprocal best hits with BLAT, LAST, and UBLAST: how much do we miss?
N Ward, G Moreno-Hagelsieb - PloS one, 2014 - journals.plos.org
Reciprocal Best Hits (RBH) are a common proxy for orthology in comparative genomics.
Essentially, a RBH is found when the proteins encoded by two genes, each in a different …
Essentially, a RBH is found when the proteins encoded by two genes, each in a different …
The cardiovascular health benefits of apples: Whole fruit vs. isolated compounds
NP Bondonno, CP Bondonno, NC Ward… - Trends in Food Science …, 2017 - Elsevier
Background Apples are an important contributor to the intake of dietary components linked
with cardiovascular disease (CVD) prevention. Apples have been shown to have beneficial …
with cardiovascular disease (CVD) prevention. Apples have been shown to have beneficial …