Background Prenatal repair of myelomeningocele, the most common form of spina bifida,
may result in better neurologic function than repair deferred until after delivery. We compared …

Despite the histological similarity of ependymomas from throughout the neuroaxis, the
disease likely comprises multiple independent entities, each with a distinct molecular …

The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent
brain, generating thousands of olfactory bulb neurons every day 1 . If the adult human brain …

Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A,
one of the two genes encoding histone H3 variant H3.3, in 60% of high-grade pediatric …

High-grade gliomas in children are different from those that arise in adults. Recent collaborative
molecular analyses of these rare cancers have revealed previously unappreciated …

OBJECT The Management of Myelomeningocele Study (MOMS) was a multicenter
randomized trial comparing the safety and efficacy of prenatal and postnatal closure of …

OBJECTIVE: Intraoperative monitoring of transcranial motor evoked potentials (TcMEPs)
has been investigated recently as a means of preventing motor deficits associated with …

Object Longer life expectancies and differences in the underlying disease in children with
aneurysms raise important issues concerning the choice of microsurgical or endovascular …

Ependymal tumors across age groups are currently classified and graded solely by histopathology.
It is, however, commonly accepted that this classification scheme has limited clinical …

The subventricular zone of many adult non-human mammals generates large numbers of
new neurons destined for the olfactory bulb 1 , 2 , 3 , 4 , 5 , 6 . Along the walls of the lateral …