Insulin-sensitive and insulin-resistant obese and non-obese phenotypes: role in prediction of incident pre-diabetes in a longitudinal biracial cohort

I Owei, N Umekwe, C Provo, J Wan… - BMJ Open Diabetes …, 2017 - drc.bmj.com
Objective We measured insulin sensitivity with euglycemic clamp (Si-clamp) in initially
normoglycemic African Americans (AA) and European Americans (EA), to probe the existence of …

Amino acid signature predictive of incident prediabetes: a case-control study nested within the longitudinal pathobiology of prediabetes in a biracial cohort

I Owei, N Umekwe, F Stentz, J Wan, S Dagogo-Jack - Metabolism, 2019 - Elsevier
Objective Circulating branched-chain amino acids (BCAAs, isoleucine, leucine, valine) and
aromatic amino acids (AAAs, tyrosine and phenylalanine) predicted type 2 diabetes mellitus (…

Awareness of prediabetes status and subsequent health behavior, body weight, and blood glucose levels

I Owei, N Umekwe, F Ceesay… - The Journal of the …, 2019 - Am Board Family Med
… HbA1c data from the 2012 National Ambulatory Medical Care Survey that targeted adults
aged >45 years without diagnosed diabetes who had an HbA1c test within 90 days (N = …

Plasma lipid levels predict dysglycemia in a biracial cohort of nondiabetic subjects: potential mechanisms

I Owei, N Umekwe, J Wan… - … Biology and Medicine, 2016 - journals.sagepub.com
Dyslipidemia and dysglycemia are etiologically associated, but the direction, chronology, and
mechanisms of the association are not fully understood. We, therefore, analyzed data from …

Outcome of lifestyle intervention in relation to duration of pre-diabetes: the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) study

S Dagogo-Jack, N Umekwe, AA Brewer… - BMJ Open Diabetes …, 2022 - drc.bmj.com
… Nkiru Umekwe1, … pre-diabetes prior to initiation of lifestyle intervention: <3 years (n=32;
23.2%), 3–5 years (n=59; 42.8%), or >5 years (n=47; 34%). Table 1 summarizes the changes in …

Multi-year reproducibility of hyperinsulinemic euglycemic clamp-derived insulin sensitivity in free-living adults: Association with incident prediabetes in the POP-ABC …

D James, N Umekwe, C Edeoga, E Nyenwe… - Metabolism, 2020 - Elsevier
Objective The hyperinsulinemic euglycemic clamp (HEC) is the “gold standard” for measuring
insulin sensitivity (Si-clamp). Here, we determined the reproducibility of serial HEC data in …

Relationships between blood pressure and blood glucose among offspring of parents with type 2 diabetes: prediction of incident dysglycemia in a biracial cohort

C Edeoga, I Owei, K Siwakoti, N Umekwe… - Journal of Diabetes and …, 2017 - Elsevier
Aims We assessed blood pressure (BP) and blood glucose (BG) values in healthy subjects,
and examined baseline BP as a predictor of incident prediabetes during follow-up. Methods …

Physiology of glycemic recovery and stabilization after hyperinsulinemic euglycemic clamp in healthy subjects

I Owei, N Jain, D Jones, N Umekwe… - The Journal of …, 2018 - academic.oup.com
Background The hyperinsulinemic euglycemic clamp (HEC) is the gold standard for measuring
insulin sensitivity, but glycemic recovery and stabilization after the procedure have not …

[HTML][HTML] Ethnic disparities in endothelial function and its cardiometabolic correlates: the pathobiology of prediabetes in a biracial cohort study

I Owei, N Umekwe, H Mohamed, S Ebenibo… - Frontiers in …, 2018 - frontiersin.org
Background Endothelial function (EF) reflects the balance between vasodilatory and
vasoconstrictive factors produced by (or acting on) the innermost lining of blood vessels. …

Plasma FGF-21 and sclerostin levels, glycemia, adiposity, and insulin sensitivity in normoglycemic black and white adults

N Umekwe, I Owei, F Stentz… - Journal of the …, 2022 - academic.oup.com
Increased circulating fibroblast growth factor (FGF)-21 and sclerostin levels have been
reported in patients with type 2 diabetes (T2D). We assessed the association of FGF-21 and …