Background Transgender individuals receive cross-sex hormonal therapy to induce desired
secondary sexual characteristics despite limited data regarding its effects on cardiovascular …

Context The efficacy and safety of testosterone replacement therapy (TRT) in hypogonadal
men remain incompletely understood. Objective To conduct a systematic review and meta-…

Background The impact of sex steroids on bone health in transgender individuals is unclear.
Methods A comprehensive search of several databases to 7 April 2015 was conducted for …

Background Eliciting patient concerns and listening carefully to them contributes to patient-centered
care. Yet, clinicians often fail to elicit the patient’s agenda and, when they do, they …

Clinical question What are the benefits and harms of thyroid hormones for adults with subclinical
hypothyroidism (SCH)? This guideline was triggered by a recent systematic review of …

Background Parathyroidectomy is a definitive treatment for primary hyperparathyroidism.
Patients contemplating this intervention will benefit from knowledge regarding the expected …

The article presents research on the use of antithyroid drugs (ATD) in treating Graves'
disease (GD) in the US Topics discussed include an overview of GD, the therapeutic effects of …

Background: Considerable uncertainty remains about the pattern of use of treatment options
for Graves' disease (GD) and their comparative effectiveness and safety. Methods: Between …

Background: Subclinical hypothyroidism (SCH) has been associated with increased risk of
adverse pregnancy outcomes in some, but not all, studies. Uncertainty remains regarding the …

Purpose To systematically appraise and summarize the available evidence about the
diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy (USFNA) for thyroid …