Objective: To test whether the association between initial serum lactate level and mortality in
patients presenting to the emergency department (ED) with severe sepsis is independent of …

Objective: To study the association between time to antibiotic administration and survival in
patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated …

We study a fixed point formalisation of the well known analysis of Bianchi. We provide a
significant simplification and generalisation of the analysis. In this more general framework, the …

Studies of acute myocardial infarction, trauma, and stroke have been translated into improved
outcomes by earlier diagnosis and application of therapy at the most proximal stage of …

BACKGROUND: Comatose survivors of out-of-hospital cardiac arrest (OHCA) have high in-hospital
mortality due to a complex pathophysiology that includes cardiovascular dysfunction, …

Objective: To define a biomarker panel to predict organ dysfunction, shock, and in-hospital
mortality in emergency department (ED) patients with suspected sepsis. Design: Prospective …

Background: Acute respiratory distress syndrome (ARDS) is a serious complication of sepsis,
and sepsis-associated ARDS is associated with significant morbidity and mortality. To date, …

Purpose We sought to generate national estimates for post-cardiac arrest mortality, to
assess trends, and to identify hospital factors associated with survival. Methods We used a …

Objectives The authors describe national trends in use, reasons for visit, most common
diagnoses, and resource utilization in patients admitted to intensive care units ( ICU s) from …

Objectives: Serum lactate values in the emergency department (ED) have been associated
with mortality in diverse populations of critically ill patients. This study investigates whether …