The development of clinically viable delivery methods presents one of the greatest challenges
in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here, we report …

The speed and scale of the global COVID-19 pandemic has resulted in unprecedented
pressures on health services worldwide, requiring new methods of service delivery during the …

Background: There has been limited acceptance of shoulder ultrasonography by orthopaedic
surgeons in the United States. The purpose of this retrospective study was to determine the …

Tumours often contain B cells and plasma cells but the antigen specificity of these
intratumoral B cells is not well understood 1 , 2 , 3 , 4 , 5 , 6 , 7 – 8 . Here we show that human …

T cells are important in tumour immunity but a better understanding is needed of the
differentiation of antigen-specific T cells in human cancer 1 , 2 . Here we studied CD8 T cells in …

Background High-level occupational exposures to some industrial chemicals have been
associated with liver diseases, including nonalcoholic fatty liver disease (NAFLD). However, the …

As endoscopic skull base resections have advanced, appropriate reconstruction has
become paramount. The reconstructive options for the skull base include both avascular and …

Surgical cancer resection requires an accurate and timely diagnosis of the cancer margins
in order to achieve successful patient remission. Hyperspectral imaging (HSI) has emerged …

Objectives/Hypothesis: A prospective study of endoscopic expanded endonasal approaches
(EEA) with nasoseptal flap reconstructions revealed anecdotal evidence of less available …

Objectives/Hypothesis: Preferred treatment of oral/plunging ranulas remains controversial.
We present our experience with ranulas at the University of North Carolina (UNC) and review …