Multi-ethnic genome-wide association study for atrial fibrillation
Atrial fibrillation (AF) affects more than 33 million individuals worldwide 1 and has a complex
heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (…
heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (…
Circadian rhythms govern cardiac repolarization and arrhythmogenesis
…, E Ficker, MJ Cutler, J Gulick, A Sanbe, J Robbins… - Nature, 2012 - nature.com
Sudden cardiac death exhibits diurnal variation in both acquired and hereditary forms of heart
disease 1 , 2 , but the molecular basis of this variation is unknown. A common mechanism …
disease 1 , 2 , but the molecular basis of this variation is unknown. A common mechanism …
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis
…, KL Wiggins, DK Arnett, MR Irvin, H Tiwari, MJ Cutler… - Nature, 2023 - nature.com
Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs),
leading to clonal haematopoiesis 1 . These lesions are precursors for blood cancers …
leading to clonal haematopoiesis 1 . These lesions are precursors for blood cancers …
Hypoxia-mediated prolonged elevation of sympathetic nerve activity after periods of intermittent hypoxic apnea
MJ Cutler, NM Swift, DM Keller… - Journal of applied …, 2004 - journals.physiology.org
Obstructive sleep apnea (OSA) is associated with transient elevation of muscle sympathetic
nerve activity (MSNA) during apneic events, which often produces elevated daytime MSNA …
nerve activity (MSNA) during apneic events, which often produces elevated daytime MSNA …
Long-term population-based cerebral ischemic event and cognitive outcomes of direct oral anticoagulants compared with warfarin among long-term anticoagulated …
…, HT May, TL Bair, BG Crandall, MJ Cutler… - The American journal of …, 2016 - Elsevier
Direct oral anticoagulants (DOACs) have been used in clinical practice in the United States
for the last 4 to 6 years. Although DOACs may be an attractive alternative to warfarin in many …
for the last 4 to 6 years. Although DOACs may be an attractive alternative to warfarin in many …
Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12. 6 knockout mice
Rationale: Abnormal calcium release from sarcoplasmic reticulum (SR) is considered an
important trigger of atrial fibrillation (AF). Whereas increased Ca 2+ /calmodulin-dependent …
important trigger of atrial fibrillation (AF). Whereas increased Ca 2+ /calmodulin-dependent …
Cardiac electrical remodeling in health and disease
MJ Cutler, D Jeyaraj, DS Rosenbaum - Trends in pharmacological …, 2011 - cell.com
Electrical remodeling of the heart takes place in response to both functional (altered electrical
activation) and structural (including heart failure and myocardial infarction) stressors. …
activation) and structural (including heart failure and myocardial infarction) stressors. …
Impact of voltage mapping to guide whether to perform ablation of the posterior wall in patients with persistent atrial fibrillation
MJ Cutler, J Johnson, K Abozguia… - Journal of …, 2016 - Wiley Online Library
Voltage‐Guided Ablation for Persistent Afib Background Fibrosis as a substrate for atrial
fibrillation (AF) has been shown in numerous preclinical models. Voltage mapping enables in …
fibrillation (AF) has been shown in numerous preclinical models. Voltage mapping enables in …
Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans
MJ Cutler, X Wan, KR Laurita, RJ Hajjar… - Circulation …, 2009 - Am Heart Assoc
Background— Beat-to-beat alternans of cellular repolarization is closely linked to ventricular
arrhythmias in humans. We hypothesized that sarcoplasmic reticulum calcium reuptake by …
arrhythmias in humans. We hypothesized that sarcoplasmic reticulum calcium reuptake by …
Targeted Sarcoplasmic Reticulum Ca2+ ATPase 2a Gene Delivery to Restore Electrical Stability in the Failing Heart
MJ Cutler, X Wan, BN Plummer, H Liu, I Deschenes… - Circulation, 2012 - Am Heart Assoc
Background— Recently, we reported that sarcoplasmic reticulum Ca 2+ ATPase 2a (SERCA2a),
the pump responsible for reuptake of cytosolic calcium during diastole, plays a central …
the pump responsible for reuptake of cytosolic calcium during diastole, plays a central …