Cellular survival: a play in three Akts
… survival through post-translational mechanisms (Datta and Greenberg 1998). However, in
vivo, … We also thank, Alex Katsov and members of the Greenberg lab for assistance with the …
vivo, … We also thank, Alex Katsov and members of the Greenberg lab for assistance with the …
The regulation and function of c-fos and other immediate early genes in the nervous system
M Sheng, ME Greenberg - Neuron, 1990 - Elsevier
The unique morphological and excitable properties of nerve cells endow them with specialized
properties that permit the reception, transmission, and storage of information. It has long …
properties that permit the reception, transmission, and storage of information. It has long …
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals
AJ Shaywitz, ME Greenberg - Annual review of biochemistry, 1999 - annualreviews.org
▪ Abstract Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the …
intracellular protein kinase cascades that phosphorylate transcription factors within the …
Regulation of neuronal survival by the serine-threonine protein kinase Akt
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes
the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) …
the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) …
[HTML][HTML] Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
…, MJ Anderson, KC Arden, J Blenis, ME Greenberg - cell, 1999 - cell.com
Survival factors can suppress apoptosis in a transcription-independent manner by activating
the serine/threonine kinase Akt, which then phosphorylates and inactivates components of …
the serine/threonine kinase Akt, which then phosphorylates and inactivates components of …
[HTML][HTML] Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
…, X Tao, S Masters, H Fu, Y Gotoh, ME Greenberg - Cell, 1997 - cell.com
Growth factors can promote cell survival by activating the phosphatidylinositide-3′-OH kinase
and its downstream target, the serine-threonine kinase Akt. However, the mechanism by …
and its downstream target, the serine-threonine kinase Akt. However, the mechanism by …
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
…, M Dickens, J Raingeaud, RJ Davis, ME Greenberg - Science, 1995 - science.org
Apoptosis plays an important role during neuronal development, and defects in apoptosis
may underlie various neurodegenerative disorders. To characterize molecular mechanisms …
may underlie various neurodegenerative disorders. To characterize molecular mechanisms …
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
The Sir2 deacetylase modulates organismal life-span in various species. However, the
molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in …
molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in …
[PDF][PDF] Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
Microglia are the resident CNS immune cells and active surveyors of the extracellular
environment. While past work has focused on the role of these cells during disease, recent …
environment. While past work has focused on the role of these cells during disease, recent …
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
ME Greenberg, EB Ziff - Nature, 1984 - nature.com
Transcription of the c-fos proto-oncogene is greatly increased within minutes of
administering purified growth factors to quiescent 3T3 cells. This stimulation is the most rapid …
administering purified growth factors to quiescent 3T3 cells. This stimulation is the most rapid …