Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to
the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer …

The 2009 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline
on the monitoring, management, and treatment of kidney transplant recipients is intended to …

This article describes ferroptosis as a previously unappreciated mechanism of action for
radiotherapy. Further, it shows that ferroptosis is a novel point of synergy between …

The ability to generate lung and airway epithelial cells from human pluripotent stem cells (hPSCs)
would have applications in regenerative medicine, modeling of lung disease, drug …

Programmed death-1 ligand (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1)
pathway blockade is a promising therapy for treating cancer. However, the mechanistic …

Two populations of Nkx2-1 + progenitors in the developing foregut endoderm give rise to the
entire postnatal lung and thyroid epithelium, but little is known about these cells because …

Directed differentiation of human embryonic stem (hES) cells and human induced pluripotent
stem (hiPS) cells captures in vivo developmental pathways for specifying lineages in vitro, …

The production of counterfeit or substandard anti-infective drugs is a widespread and under-recognised
problem that contributes to morbidity, mortality, and drug resistance, and leads …

Studies in animals suggest that the bispiperazinedione ICRF-187 can prevent the development
of dose-related doxorubicin-induced cardiac toxicity. In a randomized trial in 92 women …

PURPOSE To test potential protection by ICRF-187 against cumulative doxorubicin-dose-related
cardiac toxicity, we conducted a randomized clinical trial in 150 women with advanced …