… Author Contributions: Drs Hirschtritt and Lee contributed equally to this study, as did Drs
Scharf and Mathews. Drs Hirschtritt and Lee had full access to all the data in the study and take …

Importance Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder associated
with significant impairment and a lifetime prevalence of 1% to 3%; however, it is often …

Objective: Tourette’s syndrome is polygenic and highly heritable. Genome-wide association
study (GWAS) approaches are useful for interrogating the genetic architecture and …

Tourette syndrome (TS) is a model neuropsychiatric disorder thought to arise from abnormal
development and/or maintenance of cortico-striato-thalamo-cortical circuits. TS is highly …

Whole-exome sequencing (WES) and de novo variant detection have proven a powerful
approach to gene discovery in complex neurodevelopmental disorders. We have completed …

Older adults are more vulnerable than younger adults to the effects of substance use, including
the exacerbation of chronic medical and mental health conditions. These concerns are …

We previously established the contribution of de novo damaging sequence variants to
Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence an …

In September 2020, the US Food and Drug Administration (FDA) announced an anticipated
update to the boxed warning on all benzodiazepines to explicitly “address the serious risks …

The combined use of opioid and benzodiazepine medications increases the risk of hazardous
effects, such as respiratory depression. Although recent increases in outpatient use of …

Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving
multiple interacting genes. Here, we sought to elucidate the pathways that underlie the …