The American Thoracic Society, Centers for Disease Control and Prevention, and Infectious
Diseases Society of America jointly sponsored the development of this guideline for the …

Transient worsening of tuberculous symptomatology and lesions following antituberculous
therapy (paradoxical response) has previously been described as a rare occurrence. To …

WHO has previously recommended sputum-smear examination at the end of the second
month of treatment in patients with recently diagnosed pulmonary tuberculosis, and, if positive, …

Rationale: Reactivation tuberculosis (TB) occurs as a result of reactivation of latent TB infection
(LTBI), and was reported to occur in the United States at a rate of 0.10 to 0.16 cases per …

The clinical validity of drug susceptibility testing (DST) for pyrazinamide, ethambutol, and
second-line antituberculosis drugs is uncertain. In an individual patient data meta-analysis of …

Background. Rifapentine administered 5 days per week has potent activity in mouse models
of antituberculosis chemotherapy, but efficacy and safety data are limited in humans. We …

Background Known risk factors for death following a diagnosis of tuberculosis may not be
applicable to current US cases. We evaluated the factors associated with all-cause mortality in …

Background Evidence of an association between cigarette smoking and latent tuberculosis
infection (LTBI) is based on studies in special populations and/or from high prevalence …

Solid organ transplant (SOT) recipients are at risk for opportunistic infections including
tuberculosis. Although guidelines on the management of latent tuberculosis and active …

OBJECTIVE. Immune function and inflammatory responses often increase in AIDS patients
who receive antiretroviral therapy. We evaluated the occurrence and nature of transient …