Since 1948, when the World Health Organization defined health as being not only the
absence of disease and infirmity but also the presence of physical, mental, and social well-being, …

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …

We conducted a multicenter randomized double-blind clinical trial among 626 men with mild
to moderate hypertension to determine the effects of captopril, methyldopa, and propranolol …

Background Discontinuation rates for drugs used to treat chronic conditions may affect the
success of therapy. However, the discontinuation rates reported in clinical trials may not reflect …

Context.—Although the long-term health benefits of good glycemic control in patients with
diabetes are well documented, shorter-term quality of life (QOL) and economic savings …

OBJECTIVE: To determine whether patients with rheumatoid arthritis (RA) are at increased
risk of hospitalized infection and whether the risk varies by RA treatment. METHODS: A …

Background Reduced doses of cytotoxic chemotherapy or standard-dose therapy plus a
myeloid colony-stimulating factor decreases hematologic toxicity and its complications in …

Objective To determine whether the incidence of herpes zoster is elevated in patients with
rheumatoid arthritis (RA) and whether herpes zoster is associated with use of disease‐…

OBJECTIVE: We investigated trends in noise-induced threshold shifts (NITSs), high-frequency
hearing loss (HFHL), and low-frequency hearing loss (LFHL). METHODS: A total of 4310 …

PURPOSE To prospectively validate the AIDS Clinical Trials Group (ACTG) staging classification
for AIDS-associated Kaposi's sarcoma (KS). PATIENTS AND METHODS Two hundred …