ContextIdentification and replication of susceptibility genes for Parkinson disease at the
population level have been hampered by small studies with potential biases. α-Synuclein (SNCA…

Objective Copy number variation is a common polymorphic phenomenon within the human
genome. Although the majority of these events are non‐deleterious they can also be highly …

… treated with either 0 or 0.5 mM H2O2 for 6 hr. Labeling with 100 nM TMRE was performed
by directly adding TMRE from a DMSO stock solution (0.2 mM) to the growth medium and …

Perry syndrome consists of early-onset parkinsonism, depression, severe weight loss and
hypoventilation, with brain pathology characterized by TDP-43 immunostaining. We carried …

Elevated iron has been linked to increased morbidity and mortality in the general population
(Mainous et al, 2004). In addition, iron overload can occur as an iatrogenic consequence of …

Leucine-rich repeat kinase 2 (LRRK2) mutations have been implicated in autosomal dominant
parkinsonism, consistent with typical levodopa-responsive Parkinson's disease. The gene …

The goal of genetic association studies is to identify common (>5%) risk factors in complex
disease traits. Herein we describe the first replicable ‘functional’ risk allele for Parkinson's …

Persons with sickle cell trait (SCT) are heterozygous carriers of an abnormal ß-globin gene
that results in the production of an abnormal hemoglobin, Hb S, which can distort red blood …

Background Several genes have been implicated in the pathogenesis of Parkinson's
disease (PD). The aim of this study was to define the clinical symptoms and age-associated …

Although the issue of whether sickle cell trait (SCT) is clinically benign or a significant health
concern has not yet been resolved, the potential health risk to affected individuals is of vital …