Diagnosis and management of breast milk oversupply

L Trimeloni, J Spencer - The Journal of the American Board …, 2016 - Am Board Family Med
Managing breastfeeding problems is an essential part of newborn care. While much is
written on breast milk undersupply, little is written on oversupply, sometimes known as …

Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo

D May, S Yun, DG Gonzalez, S Park, Y Chen… - Elife, 2023 - elifesciences.org
Stem cell differentiation requires dramatic changes in gene expression and global remodeling
of chromatin architecture. How and when chromatin remodels relative to the transcriptional…

Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity

A Atmanli, D Hu, FE Deiman, AM van de Vrugt… - Elife, 2019 - elifesciences.org
10.7554/eLife.49599.001 A fundamental goal in the biological sciences is to determine how
individual cells with varied gene expression profiles and diverse functional characteristics …

[HTML][HTML] Biophysical modeling with variational autoencoders for bimodal, single-cell RNA sequencing data

M Carilli, G Gorin, Y Choi, T Chari, L Pachter - bioRxiv, 2023 - ncbi.nlm.nih.gov
We motivate and present biVI, which combines the variational autoencoder framework of
scVI with biophysically motivated, bivariate models for nascent and mature RNA distributions. …

[PDF][PDF] Modulation of the promoter activation rate dictates the transcriptional response to graded BMP signaling levels in the Drosophila embryo

C Hoppe, JR Bowles, TG Minchington, C Sutcliffe… - Developmental cell, 2020 - cell.com
Morphogen gradients specify cell fates during development, with a classic example being
the bone morphogenetic protein (BMP) gradient's conserved role in embryonic dorsal-ventral …

Transcriptional and Functional Heterogeneity During Cardiac Cellular Differentiation

A Atmanli - 2018 - search.proquest.com
… I am deeply grateful to Lauren for all his support and guidance. The experience at Tufts
fulfilled me with tremendous enthusiasm for an academic career. Special thanks to the American …

Distinguishing biophysical stochasticity from technical noise in single-cell RNA sequencing using Monod

G Gorin, L Pachter - bioRxiv, 2022 - biorxiv.org
We present the Python package Monod for the analysis of single-cell RNA sequencing count
data through biophysical modeling. Monod naturally “integrates” unspliced and spliced …

Analytical solutions of the chemical master equation with bursty production and isomerization reactions

G Gorin, L Pachter - bioRxiv, 2021 - biorxiv.org
Splicing cascades that alter gene products post-transcriptionally also affect expression
dynamics. We study a class of processes and associated distributions that emerge from a bursty …

[PDF][PDF] Monod: mechanistic analysis of single-cell RNA sequencing count data

G Gorin, L Pachter - bioRxiv, 2022 - authors.library.caltech.edu
We present the Python package Monod for the analysis of single-cell RNA sequencing count
data through chemical master equation models. Monod can effectively identify biological …

[PDF][PDF] Manejo ClíniCo da aMaMentação na atenção PriMária eM Marabá

AD da Silva Alexandre, JAC da Silva - editorapascal.com.br
Honra-me sobremaneira prefaciar o Guia Prático da Amamentação na Atenção Primária
em Marabá. Realizo-a na qualidade de admiradora pessoal da autora desta obra e …