Regenerative therapies that use allogeneic cells are likely to encounter immunological
barriers similar to those that occur with transplantation of solid organs and allogeneic …

OBJECTIVE To investigate the pharmacokinetic and pharmacodynamic properties and
safety of a novel formulation of insulin aspart (AT247) versus two currently marketed insulin …

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy
for hematological malignancies. However, graft-versus-host disease (GVHD) and relapse …

In this work we develop thermoset materials with heterogeneous microstructures on sub-micron
scales by photopolymerization-induced phase separation (photo-PIPS). To this end, we …

Immunoincompetence after allogeneic hematopoietic stem cell transplantation (HSCT) affects
in particular the T-cell lineage and is associated with an increased risk for infections, graft …

We present a strategy for adoptive immunotherapy using T-lineage committed lymphoid
precursor cells generated by Notch1-based culture. We found that allogeneic T-cell precursors …

Paradoxical to its importance for generating a diverse T cell repertoire, thymic function
progressively declines throughout life. This process has been at least partially attributed to the …

Strategies to enhance T cell recovery are of increasing clinical importance to overcome long
lasting T cell deficiencies, which occur in association with infections, autoimmunity and …

Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem
cell transplantation (HSCT). Migration of donor-derived T cells into GVHD target organs …

Taurolidine is an antimicrobial agent that was originally used in the local treatment of
peritonitis and was shown to be effective in the prevention of catheter-related bloodstream …