Background Drug overdose deaths have been rising since the early 1990s and is the leading
cause of injury death in the United States. Overdose from prescription opioids constitutes a …

PROBLEM: Overdoses involving prescription drugs in the United States have reached epidemic
proportions over the past 20years. METHODS: This review categorizes and summarizes …

… Paulozzi LJ, Ryan GW. Opioid analgesics and rates of fatal drug poisoning in the United …
Paulozzi LJ, Xi Y. Recent changes in drug poisoning mortality in the United States by urban–…

ContextDaily consumption of 400 µg of folic acid before conception and during early
pregnancy dramatically reduces the occurrence of neural tube defects (NTDs). Before food …

Context Use and abuse of prescription narcotic analgesics have increased dramatically in
the United States since 1990. The effect of this pharmacoepidemic has been most …

Purpose Since 1990, numerous jurisdictions in the United States (US) have reported increases
in drug poisoning mortality. During the same time period, the use of opioid analgesics …

This analysis confirms the predominant role opioid analgesics play in pharmaceutical overdose
deaths, either alone or in combination with other drugs. It also, however, highlights the …

Objective. Hypospadias is a common congenital anomaly, the cause of which is unknown.
Unexplained increases in the rates of hypospadias occurred in five European countries in the …

… Address correspondence to LJ. Paulozzi, Division of Birth Defects and Pediatric Genetics,
National Center for Environmental Health, Centers forDisease Control and Prevention, …

Objective. Drug overdoses resulting from the abuse of prescription opioid analgesics and
other controlled substances have increased in number as the volume of such drugs prescribed …