The genetic association database
The MMR system has evolved to increase the fidelity of DNA replication and homologous
recombination1. MMR is also implicated in the processing of other types of DNA damage, as …
recombination1. MMR is also implicated in the processing of other types of DNA damage, as …
Genetic analyses of diverse populations improves discovery for complex traits
…, N Zubair, V Acuña-Alonso, JL Ambite, KC Barnes… - Nature, 2019 - nature.com
Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …
biology of complex traits, drug development and clinical guidelines. However, the majority …
An update on the genetics of atopic dermatitis: scratching the surface in 2009
KC Barnes - Journal of Allergy and Clinical Immunology, 2010 - Elsevier
A genetic basis for atopic dermatitis (AD) has long been recognized. Historic documents allude
to family history of disease as a risk factor. Before characterization of the human genome, …
to family history of disease as a risk factor. Before characterization of the human genome, …
The genetics and complexity of allergy and asthma
KC Barnes, DG Marsh - Immunology today, 1998 - cell.com
Why do common diseases such as allergy and asthma have complex patterns of inheritance
while other, relatively uncommon diseases approximate simple Mendelian traits? There is …
while other, relatively uncommon diseases approximate simple Mendelian traits? There is …
Cytokine modulation of atopic dermatitis filaggrin skin expression
…, L Schneider, LA Beck, KC Barnes… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease that is
characterized by a defective skin barrier function. Recent studies have reported mutations of the …
characterized by a defective skin barrier function. Recent studies have reported mutations of the …
[HTML][HTML] Evidence for common genetic elements in allergic disease
KC Barnes - Journal of allergy and clinical immunology, 2000 - Elsevier
Genetic research in allergic disease has focused primarily on asthma and its associated
phenotypes (eg, total IgE), with very little attention given to the presence or absence of …
phenotypes (eg, total IgE), with very little attention given to the presence or absence of …
[PDF][PDF] Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies
S Lee, MJ Emond, MJ Bamshad, KC Barnes… - The American Journal of …, 2012 - cell.com
We propose in this paper a unified approach for testing the association between rare variants
and phenotypes in sequencing association studies. This approach maximizes power by …
and phenotypes in sequencing association studies. This approach maximizes power by …
[HTML][HTML] Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …
environmental factors. We performed a meta-analysis of North American genome-wide …
Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …
Tight junction defects in patients with atopic dermatitis
…, TH Beaty, DYM Leung, KC Barnes… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Atopic dermatitis (AD) is characterized by dry skin and a hyperactive immune
response to allergens, 2 cardinal features that are caused in part by epidermal barrier …
response to allergens, 2 cardinal features that are caused in part by epidermal barrier …