External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node …

…, K Lupe, J Goulart, D Nguyen, K Chu… - The Lancet, 2019 - thelancet.com
Background Whole breast irradiation delivered once per day over 3–5 weeks after breast
conserving surgery reduces local recurrence with good cosmetic results. Accelerated partial …

Intravitreal aflibercept for macular edema following branch retinal vein occlusion: the 24-week results of the VIBRANT study

…, R Vitti, H Kazmi, AJ Berliner, K Erickson, KW Chu… - Ophthalmology, 2015 - Elsevier
Purpose To compare the efficacy and safety of intravitreal aflibercept injection (IAI) with macular
grid laser photocoagulation for the treatment of macular edema after branch retinal vein …

Intravitreal aflibercept for macular edema following branch retinal vein occlusion: 52-week results of the VIBRANT study

…, R Vitti, H Kazmi, AJ Berliner, K Erickson, KW Chu… - Ophthalmology, 2016 - Elsevier
Purpose To determine week 52 efficacy and safety outcomes in eyes with macular edema
after branch retinal vein occlusion (BRVO) treated with 2 mg intravitreal aflibercept injection (…

Evaluation of intravitreal aflibercept for the treatment of severe nonproliferative diabetic retinopathy: results from the PANORAMA randomized clinical trial

…, GD Yancopoulos, AJ Berliner, K Chu… - JAMA …, 2021 - jamanetwork.com
Importance Proactive treatment of nonproliferative diabetic retinopathy (NPDR) reduces the
risk of progression to vision-threatening complications. Objective To evaluate vascular …

Quantitative self-assembly prediction yields targeted nanomedicines

…, KS Ganesh, DC Johnson, R Sridharan, KL Chu… - Nature materials, 2018 - nature.com
Abstract Development of targeted nanoparticle drug carriers often requires complex synthetic
schemes involving both supramolecular self-assembly and chemical modification. These …

Effect of intravitreal aflibercept vs laser photocoagulation on treatment success of retinopathy of prematurity: the FIREFLEYE randomized clinical trial

…, J Mazela, DM Moshfeghi, R Vitti, A Athanikar, K Chu… - Jama, 2022 - jamanetwork.com
Importance Laser photocoagulation, which is the standard treatment for retinopathy of
prematurity (ROP), can have adverse events. Studies of anti–vascular endothelial growth factor …

TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid …

…, C Guha, N Bayol, M Gillen, K Chu… - Journal of clinical …, 2004 - ascopubs.org
Purpose TNFerade is a replication deficient adenovector that expresses human tumor
necrosis factor alpha under control of the radiation-inducible Egr-1 promoter. The goals of this …

A Critical Role for Neutrophils in Resistance to Experimental Infection with Burkholderia pseudomallei

A Easton, A Haque, K Chu… - The Journal of …, 2007 - academic.oup.com
Inhalation is an important route of infection with Burkholderia pseudomallei the causative
agent of melioidosis. In resistant C57BL/6 mice, activated neutrophils are rapidly recruited to …

A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular …

…, SM Shah, G Hafiz, E Quinlan, J Sung, K Chu… - Ophthalmology, 2006 - Elsevier
OBJECTIVES: To assess the safety, pharmacokinetics, and biological activity of IV
administration of vascular endothelial growth factor trap (VEGF Trap), a recombinant protein …

[PDF][PDF] N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

Y Cheng, W Xie, BF Pickering, KL Chu, AM Savino… - Cancer cell, 2021 - cell.com
N 6 -Methyladenosine (m 6 A) on mRNAs mediates different biological processes and its
dysregulation contributes to tumorigenesis. How m 6 A dictates its diverse molecular and …