We have combined long synthetic arrays of alpha satellite DNA with telomeric DNA and
genomic DNA to generate artificial chromosomes in human HT1080 cells. The resulting linear …

Introduction: This guideline establishes clinical practice recommendations for the use of
behavioral and psychological treatments for chronic insomnia disorder in adults. Methods: The …

The C family G-protein-coupled receptors contain members that sense amino acid and
extracellular cations, of which calcium-sensing receptor (CASR) is the prototypic extracellular …

Background GPRC6A is a widely expressed orphan G-protein coupled receptor that senses
extracellular amino acids, osteocalcin and divalent cations in vitro. The physiological …

Introduction: The purpose of this systematic review is to provide supporting evidence for a
clinical practice guideline on the use of behavioral and psychological treatments for chronic …

Structure-specific nucleases catalyze critical reactions in DNA replication, recombination,
and repair. Recently, a structure-specific endonuclease, FEN-1, has been purified and shown …

Background: The prevalence and nature of sleep disorders in primary care has not been
widely studied. As part of a survey conducted in 5 family practice offices in North Carolina, we …

Obstructive sleep apnea (OSA) is a relatively common breathing disorder known to increase
in prevalence with obesity and age. 1, 2 The repetitive interruptions in breathing typically …

Opinion statement Sleep disorders are common among the elderly and are associated with
diminished quality of life, increased risk for development of psychiatric disorders, …

Sleep disturbances are common among older adults. The elderly population reports more
symptoms associated with poor sleep initiation and maintenance and increased daytime …