Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis
…, PC Heinrich, HF Merk, A Bosio, JM Baron… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: IL-31 is produced by activated T lymphocytes, preferentially by T H 2 cells.
Transgenic mice overexpressing IL-31 have a phenotype resembling allergic dermatitis in …
Transgenic mice overexpressing IL-31 have a phenotype resembling allergic dermatitis in …
IL-31 regulates differentiation and filaggrin expression in human organotypic skin models
…, J Frank, J Lüscher-Firzlaff, B Lüscher, JM Baron - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disease affecting 10% to 20%
of children and 1% to 3% of adults in industrialized countries. Enhanced expression of IL-…
of children and 1% to 3% of adults in industrialized countries. Enhanced expression of IL-…
[HTML][HTML] Expression of multiple cytochrome p450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes
JM Baron, D HoÈller, R Schiffer, S Frankenberg… - Journal of Investigative …, 2001 - Elsevier
Cytochrome P450 enzymes metabolize various endogenous and exogenous small molecular
weight compounds. Transport-associated proteins, such as P-glycoprotein, multidrug …
weight compounds. Transport-associated proteins, such as P-glycoprotein, multidrug …
Y‐box protein‐1 is actively secreted through a non‐classical pathway and acts as an extracellular mitogen
…, U Raffetseder, A En‐Nia, H Knott, JM Baron… - EMBO …, 2009 - embopress.org
Y‐box protein (YB)‐1 of the cold‐shock protein family functions in gene transcription and RNA
processing. Extracellular functions have not been reported, but the YB‐1 staining pattern …
processing. Extracellular functions have not been reported, but the YB‐1 staining pattern …
Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ
…, JM Baron, A Alase, M Wittmann… - Proceedings of the …, 2017 - National Acad Sciences
The proinflammatory cytokine IL-36γ is highly expressed in epithelial cells and is a pivotal
mediator of epithelial inflammation. In particular, IL-36γ is strongly associated with the …
mediator of epithelial inflammation. In particular, IL-36γ is strongly associated with the …
[HTML][HTML] The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and function
CM Pfaff, Y Marquardt, K Fietkau, JM Baron… - Scientific reports, 2017 - nature.com
Psoriasis is a T H 17-driven inflammatory disease affecting a significant proportion of the
world population. The molecular consequences of IL-17 signaling in the skin are only partially …
world population. The molecular consequences of IL-17 signaling in the skin are only partially …
Retinoid treatment of skin diseases
L Beckenbach, JM Baron, HF Merk, H Löffler… - European Journal of …, 2015 - Springer
Retinoids (vitamin A and its metabolites) are potent natural regulators of cellular activities,
including cell growth and differentiation, and they mediate many essential regulatory functions…
including cell growth and differentiation, and they mediate many essential regulatory functions…
Cytochrome P450 1B1: a major P450 isoenzyme in human blood monocytes and macrophage subsets
JM Baron, G Zwadlo-Klarwasser, F Jugert… - Biochemical …, 1998 - Elsevier
In this study, cytochrome P450 (CYP; EC 1.14.14.1)-dependent activities and P450 isoenzyme
patterns were determined in human monocytes and macrophages, which play a major …
patterns were determined in human monocytes and macrophages, which play a major …
Characterization of a novel standardized human three‐dimensional skin wound healing model using non‐sequential fractional ultrapulsed CO2 laser treatments
…, HF Merk, C Skazik‐Voogt, JM Baron - Lasers in surgery …, 2015 - Wiley Online Library
Background and Objective At present, there is no standardized in vitro human skin model for
wound healing. Therefore, our aim was to establish and characterize an in vitro/ex vivo three…
wound healing. Therefore, our aim was to establish and characterize an in vitro/ex vivo three…
Control of the physical and antimicrobial skin barrier by an IL-31–IL-1 signaling network
…, K Czaja, A Kim, B Lüscher, JM Baron - The Journal of …, 2016 - journals.aai.org
Atopic dermatitis, a chronic inflammatory skin disease with increasing prevalence, is closely
associated with skin barrier defects. A cytokine related to disease severity and inhibition of …
associated with skin barrier defects. A cytokine related to disease severity and inhibition of …