DNA recombination and repair pathways require structure-specific endonucleases to process
DNA structures that include forks, flaps, and Holliday junctions. Previously, we determined …

Repair of DNA double-strand breaks (DSBs) must be properly orchestrated in diverse
chromatin regions to maintain genome stability. The choice between two main DSB repair …

Genomic integrity often is compromised in tumor cells, as illustrated by genetic alterations
leading to loss of heterozygosity (LOH). One mechanism of LOH is mitotic crossover …

Disruption of cell cycle checkpoints has been well established as a hallmark of cancer. In
particular, the G1-S transition mediated by the cyclin D-cyclin-dependent kinase 4/6 (CDK4/6) …

Double-strand breaks (DSBs) must be accurately and efficiently repaired to maintain genome
integrity. Depending on the organism receiving the break, the genomic location of the DSB, …

Aging is characterized by genome instability, which contributes to cancer formation and cell
lethality leading to organismal decline. The high levels of DNA double‐strand breaks ( DSB s…

Bloom syndrome is a rare disorder associated with cancer predisposition and genomic
instability and is caused by loss of the RecQ helicase BLM. The Drosophila ortholog of BLM (…

The ability of a cell to sense and respond to DNA damage is essential for genome stability.
An important aspect of the response is arrest of the cell cycle, presumably to allow time for …

Double-strand breaks (DSBs) are particularly deleterious DNA lesions for which cells have
developed multiple mechanisms of repair. One major mechanism of DSB repair in …

Germ cells are maintained in a pristine non-aging state as they proliferate over generations.
Here, we show that a novel function of the Caenorhabditis elegans RNA interference …