This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …

Despite the greater information content of genomic DNA, ancient DNA studies have largely
been limited to the amplification of mitochondrial sequences. Here we describe metagenomic …

Embryonic gene expression intricately reflects anatomical context, developmental stage,
and cell type. To address whether the precise spatial origins of cardiac cells can be deduced …

Background As whole exome sequencing (WES) and whole genome sequencing (WGS)
transition from research tools to clinical diagnostic tests, it is increasingly critical for sequencing …

Background: Low birthweight has been associated with a higher risk of hypertension, type 2
diabetes mellitus (T2D), and cardiovascular disease. The Barker hypothesis posits that …

Biomedical repositories such as the UK Biobank provide increasing access to prospectively
collected cardiac imaging, however these data are unlabeled, which creates barriers to their …

BACKGROUND: Only some patients with coronary artery disease (CAD) develop acute
myocardial infarction (MI), and emerging evidence suggests vulnerability to MI varies …

Congenital heart disease (CHD) has a complex genetic etiology, and recent studies suggest
that high penetrance de novo mutations may account for only a small fraction of disease. In …

Congenital heart disease (CHD) is the most common anatomical malformation occurring live‐born
infants and an increasing cause of morbidity and mortality across the lifespan and …

Atherosclerosis is the process underlying heart attack and stroke. Despite decades of research,
its pathogenesis remains unclear. Dogma suggests that atherosclerotic plaques expand …